For years, the standard testosterone replacement therapy (TRT) protocol has been a once-a-week injection. While this may seem convenient, it often leads to unstable hormone levels, unnecessary side effects, and poor symptom relief. If you’re on TRT and still experiencing ups and downs, it’s time to rethink the “one-size-fits-all” approach. Testosterone protocols should be tailored to your individual needs, taking into account factors like free testosterone, sex hormone-binding globulin (SHBG), and lifestyle.
Why Once-a-Week Injections Are Problematic
When you inject testosterone once a week, your hormone levels spike quickly and then decline before your next dose. This rollercoaster effect can lead to:
More Side Effects – Higher peaks mean more side effects like bloating, mood swings and elevated hematocrit
Fluctuating Energy and Mood – Many men feel great for a few days post-injection, only to crash as their levels drop.
Inconsistent Symptom Relief – TRT is meant to eliminate symptoms of low testosterone, but if your levels aren't stable, neither is your relief.
The Importance of Personalization
Instead of a cookie-cutter protocol, TRT should be based on:
Free Testosterone Levels – Total testosterone isn’t the whole story. Free testosterone (the active form) is what truly determines how you feel.
SHBG (Sex Hormone-Binding Globulin) – SHBG controls how much testosterone is available to your body. Frequency of injections will be determined by your SHBG levels.
Lifestyle Factors – Sleep, diet, stress, and exercise all impact testosterone metabolism. Your TRT plan should work with your lifestyle, not against it.
A Smarter Approach to TRT
For most men, smaller, more frequent injections (such as twice weekly, three times a week or even every other day) lead to:
More Stable Hormone Levels – No more highs and lows—just steady, optimal testosterone.
Fewer Side Effects – Less aromatization to estrogen and a smoother overall experience.
Better Symptom Control – Say goodbye to crashes and fatigue.
The Bottom Line
If you’re still following the once-a-week harpoon madness, it’s time to reconsider. A personalized TRT protocol based on your unique physiology can make all the difference in symptom relief, performance, and overall well-being. At Metromed, we specialize in customized TRT protocols that ensure you get the best results with the fewest side effects.
It’s time to ditch the outdated once-a-week protocol and experience the benefits of a truly optimized approach. Ready to take control of your TRT journey? Contact us today!
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